Wang Lei

Personal profile: 
       Associate Professor Wang Lei received his Ph.D. in Biochemistry and Molecular Biology from Sun Yat-Sen University in 2004. From September 2004 to September 2015, he was engaged in the research of medical molecular biology and marine functional genes at the School of Life Sciences of Sun Yat-Sen University. Associate professor of the School of Science, master's tutor. In 2010, he was selected as a school-level candidate for the “Thousand Talents Training Project”. In 2011, he went to the Faculty of Medicine of Virginia Commonwealth University for a one-year study of visiting scholars. In September 2015, he was transferred to the South China Agricultural University, mainly engaged in research work on marine biological functional genes and aquaculture immunomodulation biological agents. He has presided over the National Natural Science Foundation Project (300,000), Marine 863 Program (880,000), National Science and Technology Support Program 12th Five-Year Marine Fisheries and Beach Utilization Special (8.26 million), Guangdong Province Ocean The scientific and technological development of regional demonstration projects (575 million) and other scientific research projects, and achieved a number of important original results. A total of 26 related SCI papers were published. As the main inventor, he obtained 20 national invention patents related to marine biological function genes. Independently supervised 5 postgraduates, assisted in guiding 4 doctoral students and 6 postgraduates. As a lecturer, he has undertaken the compulsory course for undergraduate students of the School of Life Sciences of Sun Yat-Sen University, Biotechnology Comprehensive Experiment, Progress in Modern Biotechnology, Professional Elective Course Medical Molecular Biology, and Master of Engineering Master's Course Progress in Bioengineering Teaching work. At present, he has undertaken the teaching of courses such as “Marine Biopharmaceuticals”, “Drug Toxicology” and “Biotechnology Drugs” of South China Agricultural University.

Current research directions: 
1. Research and development of marine biological active substances 
2. Research and development of active medicinal plant active substances

Some representative papers: 
1. Wang L #, Zou Q, Wang J, Zhang J, Liu Z, Chen X #. The Proteomic Profiles Reveal the Function of Different Vegetative Tissues of Moringa oleifera. The Protein Journal. DOI 10.1007/s10930- 016-9690-x. (Accepted on Nov. 2. 2016)  
2.Wang L, Tang W, Wang X, Chen Y, Wu Y, Yuanyuan Qiang, Yuchao Feng, Ren Z, Chen S, Xu A.* PPIase is Associated with the diversity of conotoxins from cone snail venom glands. Biochimie. 2015 Mar 11. pii: S0300-9084(15)00059-0. doi: 10.1016/j.biochi.2015.02.024. (Accepted on March 1,2015) . 
3.Ren the Z, Wang L *, M Written by Qin, by You the Y, Pan W is, Zhou L, D the Sun, The Pharmacological Characterization of A. Xu AS A potent conotoxin lt14a non-Toxicon, 2015 Jan 22 is Addictive Analgesic; 96C:.. 57 is -67. doi: 10.1016/j.toxicon.2015.01.013. 
4.Wang L, Liu J, Pi C, Zeng X, Zhou M, Jiang X, Chen S, Ren Z, Xu A*. Identification of a novel M-superfamily conotoxin with the ability to enhance tetrodotoxin sensitive sodium currents. Arch Toxicol 2009;83(10):925-32. 
5.Wang L, Pi C, Liu J, Chen S, Peng C, Sun D, Zhou M, Xiang H, Ren Z, Xu A*. Identification and characterization of a Novel O-superfamily conotoxin from Conus litteratus. J Pept Sci. 2008 ;14(10):1077-83. 
6. Wang L, Lai C, Wu Q, Liu J, Zhou M, Ren Z, Sun D, Chen S, Xu A*. Production and characterization of a novel secretariat peptide HKABF by Pichia pastoris. Process Biochemistry, 2008; 43:1124-1131.
7.Zhou M, Wang L, Wu Y, Liu J, Sun D, Zhu X, Feng Y, Qin M, Chen S, Xu A. Soluble expression and sodium channel activity of lt16a, a novel framework XVI conotoxin from the M- Superfamily. Toxicon. 2015 Jan 16. pii: S0041-0101(15)00012-4. doi: 0.1016/j.toxicon.2015.01.009. 
8.Wu Y, Wang L, Zhou M, Jiang X, Zhu X, Chen Y, Luo S, You Y, Ren Z, Xu A. Soluble expression, purification and functional identification of the framework XV conotoxins derived from different Conus species. Peptides. 2014; 56:77-83.  
9.Wu Y, Wang L, Zhou M, You Y, Zhu X, Qiang Y, Qin M, Luo S, Ren Z, Xu A. Molecular evolution and diversity of conus Peptide toxins, as revealed by gene structure and intron sequence analyses. PLoS One. 2013 Dec 13; 8(12): e82495. doi: 10.1371/journal.pone.0082495. 
10.Zhou M, Wang L, Wu Y, Zhu X, Feng Y, Chen Z, Li Y, Sun D, Ren Z, Xu A. Characterizing the evolution and functions of the M-superfamily conotoxins.Toxicon. 2013; 76: 150-9.

Hosting the topic: 
1. Name of the project: Development and application of biological preparations for marine aquatic disease prevention and control. No. 2012BAD17B02, Science and Technology Support Program (Marine Agriculture), 8.26 million. 2012.1-2015.12. 
2. Name of the project: Laboratory of microbial functional gene screening technology. No.: GD2012-D01-002, the public fishery service platform project of the Marine Fisheries Bureau, 5.75 million. 2013.6-2016.6. 
3. Title: Molecular mechanism and function of signal conotoxin lt5d and sodium ion channel number: 30797921. National Natural Science Foundation of China. 2009.1-2011.12, 300,000. 
4. Name of the project: Research and development of the signal medicinal gene of the snail. Number: 2008AA09Z401 Ocean 863 special project, 880,000. 2008.8-2010.12 months. 
5. Name of the project: Excavation and application technology of key genes for important production traits No.: 2006AA10A402 2006.12.01-2010.10.10 863 marine special sub-project, 250,000. 
6. Title: Post-translational modification function and mechanism of conotoxin polypeptide Research No.: 2015A030313191 2015.8.1-2018.8.1 Guangdong Provincial Natural Science Foundation, 100,000. 
7. Title of the project: Research on the production of feed additives using Moringa as a protein source, 2016.6-2020.6, 400,000, horizontal subject.